TalkSoup is a fully configurable graphical IRC client for both GNUstep and Mac OS X. Its simplistic interface is made extremely powerful by the fact that all parts of the IRC client are implemented as runtime-loaded plugins, so additional plugins can be made to further extend TalkSoup. TalkSoup supports a tabbed interface, DCC file transfer, and most common features found in other IRC clients.
WSN InstaChat is an experimental new kind of chat where you can watch others typing rich text in real time. Use rich text formatting, images, spell check, tables, bullet points, lists, Flash objects, smilies, and more in your chat. Collaborate with other people, either one on one or with a large group. Installation is as easy as copying the files to your Web server.
irofferTNG is a new, more active branch of the iroffer development. Totally independant from iroffer, it is a more general-purpose bot. It uses loadable modules as plugins, with security and stability on mind. It has support for XDCC-style commands, very good performance serving multiple files through DCC, and a lot of cool features like DCC partyline, MySQL support, etc.